IntroductionCognitive impairment is a highly prevalent non-motor feature of Parkinson’s disease. A better understanding of the underlying pathophysiology may help in identifying therapeutic targets to prevent or treat dementia. This study sought to identify metabolic alterations in the prefrontal cortex, a key region for cognitive functioning that has been implicated in cognitive dysfunction in PD.MethodsProton Magnetic Resonance Spectroscopy was used to investigate metabolic changes in the PFC of a cohort of cognitively normal individuals without PD, as well as PD participants (...) with either normal cognition, mild cognitive impairment, or dementia. Ratios to Creatine resonance were obtained for glutamate, glutamine and glutamate combined, N-acetylaspartate, myoinositol, and total choline, and correlated with cognitive scores across multiple domains administered to the PD participants only.ResultsWhen individuals retain cognitive capabilities, the presence of Parkinson’s disease does not create metabolic disturbances in the PFC. However, when cognitive symptoms are present, PFC Glu/Cre ratios decrease with significant differences between the PD-NC and PPD groups. In addition, Glu/Cre ratios and memory scores were marginally associated, but not after Bonferroni correction.ConclusionThese preliminary findings indicate that fluctuations in prefrontal glutamate may constitute a biomarker for the progression of cognitive impairments in PD. We caution for larger MRS investigations of carefully defined PD groups. (shrink)

Psychiatry is rapidly adopting digital phenotyping and artificial intelligence/machine learning tools to study mental illness based on tracking participants’ locations, online activity, phone and text message usage, heart rate, sleep, physical activity, and more. Existing ethical frameworks for return of individual research results (IRRs) are inadequate to guide researchers for when, if, and how to return this unprecedented number of potentially sensitive results about each participant’s real-world behavior. To address this gap, we convened an interdisciplinary expert working group, supported by (...) a National Institute of Mental Health grant. Building on established guidelines and the emerging norm of returning results in participant-centered research, we present a novel framework specific to the ethical, legal, and social implications of returning IRRs in digital phenotyping research. Our framework offers researchers, clinicians, and Institutional Review Boards (IRBs) urgently needed guidance, and the principles developed here in the context of psychiatry will be readily adaptable to other therapeutic areas. (shrink)

Developing countries face numerous barriers to conducting effective and efficient ethics reviews of international collaborative research. In addition to potentially overlooking important scientific and ethical considerations, inadequate or insufficiently trained ethics committees may insist on unwarranted changes to protocols that can impair a study's scientific or ethical validity. Moreover, poorly functioning review systems can impose substantial delays on the commencement of research, which needlessly undermine the development of new interventions for urgent medical needs. In response to these concerns, the Drugs (...) for Neglected Diseases Initiative, an independent nonprofit organization founded by a coalition of public sector and international organizations, developed a mechanism to facilitate more effective and efficient host country ethics review for a study of the use of fexinidazole for the treatment of late stage African Trypanosomiasis. The project involved the implementation of a novel ‘pre-review’ process of ethical oversight, conducted by an ad hoc committee of ethics committee representatives from African and European countries, in collaboration with internationally recognized scientific experts. This article examines the process and outcomes of this collaborative process. (shrink)

In matters such as affirmative action or home schooling, rights of ethnic and other minority groups often come into conflict with those of society in a culturally diverse population such as ours. But before considering the dilemmas posed by these issues, we must first ask such basic but important questions as what group rights are and how they intersect with the principles of democracy. This new collection brings together some of today's leading thinkers from the cutting edge of these debates, (...) taking in a broad range of issues confronting philosophers, sociologists, and political scientists. Contributors such as Carl Wellman, Carol Gould, and Rex Martin examine the nature of groups and the conflict between group rights and democracy and also consider case studies depicting current issues in cultural, ethnic, and religious rights. The first section, on the nature of groups, examines some of the perplexing alternatives in the formulation of a theory of group rights. These articles investigate the kinds of rights minorities might claim and ask when groups can be held responsible for the acts of some of their members. The second section addresses the treatment of groups in a democracy and the precarious balance between indifference toward minorities and capitulation to their demands. Here the contributors examine five principles for the sensitive treatment of minority and disadvantaged groups in a democratic society. A final section explores specific conflicts between subgroup and societal claims through case studies dealing with affirmative action, religious practice and the education of children, and the land rights of indigenous peoples. By drawing on the legal and political dilemmas related to these cases, the authors confront issues of core versus peripheral interests, of individual member versus subgroup rights, and of the possibilities for social openness raised in the preceding sections Written from varied perspectives, Groups and Group Rights offers stimulating reading for both students and professionals as it takes on some of the most pressing dilemmas confronting our society. (shrink)

Using the philosophy of Jean-Luc Nancy as an anchoring point, Jacques Derrida in this book conducts a profound review of the philosophy of the sense of touch, from Plato and Aristotle to Jean-Luc Nancy, whose ground-breaking book _Corpus_ he discusses in detail. Emmanuel Levinas, Maurice Merleau-Ponty, Edmund Husserl, Didier Franck, Martin Heidegger, Francoise Dastur, and Jean-Louis Chrétien are discussed, as are René Descartes, Diderot, Maine de Biran, Félix Ravaisson, Immanuel Kant, Sigmund Freud, and others. The scope of Derrida's deliberations (...) makes this book a virtual encyclopedia of the philosophy of touch. Derrida gives special consideration to the thinking of touch in Christianity and, in discussing Jean-Luc Nancy's essay "Deconstruction of Christianity," devotes a section of the book to the sense of touch in the Gospels. Another section concentrates on "the flesh," as treated by Merleau-Ponty and others in his wake. Derrida's critique of intuitionism, notably in the phenomenological tradition, is one of the guiding threads of the book. _On Touching_ includes a wealth of notes that provide an extremely useful bibliographical resource. Personal and detached all at once, this book, one of the first published in English translation after Jacques Derrida's death, serves as a useful and poignant retrospective on the work of the philosopher. A tribute by Jean-Luc Nancy, written a day after Jacques Derrida's death, is an added feature. (shrink)

How do multiple obligations to give, to receive, and to reciprocate contribute to the evolution of international society? This question can be derived from the works of the French anthropologist and sociologist Marcel Mauss, in particular from his classic essay The Gift, published in 1925. The aim of this article is to introduce Mauss’ theory of the gift to international political theorists, to develop a general theoretical argument from his claim about the universality of gift-giving, and to lay out the (...) plan of the Special Issue. First, we explore the basic concepts of gift-giving and reciprocity and how they highlight a type of exchange that differs from market exchange and from other forms of quid-pro-quo interactions. Second, we consider the Marshall Plan as an iconic and controversial example of international gift-giving. Third, we use Martin Wight’s division of international political thought into realism, rationalism, and revolutionism to locate the work of Mauss and neo-Maussian scholars within th... (shrink)

Pacific Philosophical Quarterly, March 2006. Significant effort has been devoted to locating a good argument for Kant ’s Formula of Humanity. In this paper, I contrast two arguments, based on Kant ’s text, for the Formula of Humanity. The first, which I call the “Valued Ends” argument, is an influential and appealing argument developed most notably by Christine Korsgaard and Allen Wood. Notwithstanding the appeal and influence of this argument, it ultimately fails on several counts. I therefore present as (...) an alternative the “Autonomy” argument, which is largely inspired by the failings of the Valued Ends argument. (shrink)

Dialogue between feminist and mainstream philosophy of science has been limited in recent years, although feminist and mainstream traditions each have engaged in rich debates about key concepts and their efficacy. Noteworthy criticisms of concepts like objectivity, consensus, justification, and discovery can be found in the work of philosophers of science including Philip Kitcher, Helen Longino, Peter Galison, Alison Wylie, Lorraine Daston, and Sandra Harding. As a graduate student in philosophy of science who worked in both literatures, I was often (...) left with the feeling that I had joined a broken family with two warring factions. This is apparent in the number of anthologies that have emerged on both sides in the aftermath of the “Science Wars” (Gross, Paul R., Norman Levitt, and Martin W. Lewis, eds. 1996; Koertge, Noretta, ed. 1998; Sokal, Alan and Jean Bricmont. 1998; etc.) Depending on one’s perspective on the Science Wars, the breadth of illustrative cases and examples found in Science and Other Cultures can either give more ammunition for the battle, or grounding for a much needed treaty of accord. The most important feature of this book is that it does not merely claim that science is only political, and it does not merely dismiss science as a social phenomenon to be deconstructed using the standard postmodern conceptual tools. Instead, the collection illustrates ways in which postcolonial analysis and multicultural examples can enrich our understanding of “good” science and ethics. Here, the concept of “strong objectivity” from Harding’s earlier books is fleshed out through a variety of cases. The anthology is the culmination of a series of research activities funded by a National Science Foundation grant to the American Philosophical Association. The grant, under the auspices of the NSF Ethics and Values Program, sponsored fourteen summer research projects and thirty-six presentations at four regional APA meetings. (shrink)

Grounded in a close reading of the records of Joan's trial and rehabilitation, on the early letters announcing her arrival at Chinon, and on three literary works; Christine de Pizan's Ditié, Martin le Franc's Le Champion des dames, and Alain Chartier's, Traité de l’Esperance, this controversial work argues that serious historians should accept that Joan was trained. It proposes that she was identified and taught how to behave in the expectation of the fulfillment of the Charlemagne Prophecy and (...) other prophecies from the Joachite tradition. It explores the possibility that Christine de Pizan, who had been promoting these prophecies from the beginning of the century, had some hand in the process that resulted in Joan's appearance and demonstrates, at the very least, that there are many links connecting Christine de Pizan to the knights who fought with Joan. (shrink)

Die Vermittlung ethischer Kompetenzen ist wesentlicher Bestandteil in berufsqualifizierenden und postgraduellen Studiengängen. Dabei werden praktisch-ethische Problemlösungskompetenzen, je nach Studiengang aber auch die forschungsethische Betrachtung von Studien thematisiert. Die Überprüfung dieser ethischen Kompetenzen stellt sich als Herausforderung dar. Das schriftliche oder mündliche Abfragen von Lehrinhalten greift zu kurz, da somit lediglich Wissen, jedoch nicht Fertigkeiten oder gar Haltung erfasst werden können.Bei der Reakkreditierung des Masterstudiengangs Pflegewissenschaft an der Universität Witten/Herdecke wurde dieser Herausforderung mit der Umsetzung eines für die postgraduelle Ausbildung innovativen (...) Prüfungsformats begegnet. Für das Modul „Ethik in der Pflegepraxis und -forschung“ wurde ein Format ausgearbeitet, welches sich an den „Objective Structured Clinical Examinations“ orientiert und somit die erworbenen Fertigkeiten und Haltungen der Studierenden mit einbezieht. Der Beitrag zeigt auf, wie das OSCE-Prüfungsformat konzipiert und eine Adaption erfolgt ist. (shrink)

Background Teaching ethical competencies is an essential component of professional and postgraduate curricula. Developing practical–ethical problem-solving competencies as well as appraising program-specific studies and related research ethics are topics typically addressed. However, assessment of these ethical competencies poses a challenge. Written or oral assessment formats addressing relevant learning objectives is mainly limited to knowledge testing alone, often not capturing relevant skills or attitudes pertinent to those competencies. Aim During the reaccreditation of the masters of science program in Nursing Science at (...) Witten/Herdecke University, this challenge was addressed by implementation of an innovative examination format for postgraduate education. Procedure For the module “Ethics in nursing practice and research” a format based on the Objective Structured Clinical Examination format was developed. This assessment method incorporates evaluation of acquired skills and attitudes of nursing students. Conclusion The article demonstrates development and adaption of the OSCE format for this purpose. (shrink)

Here, we describe how Casas Grandes Medio period (AD 1200 to 1450) shamanic practices of the North American Southwest used tobacco shamanism, a ritual stance called the Tennessee Diviner (TD) posture, and cultural expectations to generate trance experiences of soul flight and divination. We introduce a conceptual model that holds that specific trance experiences are the emergent result of human minds interacting with additional factors including entheogens, cultural expectations, physiological states, postures/movement, and sound/stimulation. Experimental and ethnographic evidence indicates initiating trance (...) with either tobacco intoxication or the TD posture accompanied with a rapidly beating drum or rattle corresponds with perceptions of soul flight, transformation, and divination/information acquisition. Both have similar results but pairing them together as they were during the Medio period likely helped ensure the culturally desired trance experiences. This practice of mutually reinforcing factors was likely part of tobacco‐based shamanism found in other New World cultures as well. We suggest our general model can be applied to other contexts to examine how various aspects of trance induction interact to produce the cultural patterns (and resulting cosmological and spiritual frameworks) anthropologists have documented in other cultures. (shrink)

Die Beiträge aus den unterschiedlichsten Wissenschaftsdisziplinen zeigen, dass Ideologien von jeher Wahrheitsansprüche formulierten, die im Verlauf ihrer Wirkungsgeschichte entweder als Irrtümer buchstäblich "Lügen gestraft" wurden oder von zeitgenössischen ideologischen Gegenentwürfen als solche bezeichnet wurden.

Family Medicine Groups (FMGs) are the most recently developed primary care organizations in Quebec (Canada). Nurses within FMGs play a central role for patients with chronic diseases (CD). However, this complex role and the nursing activities related to this role vary across FMGs. Inadequate knowledge of nursing activities limits the implementation of exemplary nursing practices. This study aimed to describe FMG nursing activities with patients with CD and to describe the facilitators and barriers to these activities. A multiple‐case study was (...) performed with ten nurses practicing among patients with CD in FMGs. Five data sources were used to provide an in‐depth description of nursing activities and the facilitators and barriers to the development of these activities. After qualitative data analysis, findings show that nursing activities are clustered into five domains: Global assessment of the patient, Care management, Health promotion, Nurse–physician collaboration, and Planning services for patients with CD. Activities vary depending on contextual factors identified in each case. This multiple‐case study provides a clear description of nursing activities with patients with CD. There is a need for improved nursing activities and expertise in domains of activities that are less present in FMGs, such as case management and interprofessional collaboration. (shrink)

There is widespread agreement in neuroscience and psychology that the visual system identifies objects and faces based on a pattern of activation over many neurons, each neuron being involved in representing many different categories. The hypothesis that the visual system includes finely tuned neurons for specific objects or faces for the sake of identification, so‐called “grandmother cells”, is widely rejected. Here it is argued that the rejection of grandmother cells is premature. Grandmother cells constitute a hypothesis of how familiar visual (...) categories are identified, but the primary evidence against this hypothesis comes from studies that have failed to observe neurons that selectively respond to unfamiliar stimuli. These findings are reviewed and it is shown that they are irrelevant. Neuroscientists need to better understand existing models of face and object identification that include grandmother cells and then compare the selectivity of these units with single neurons responding to stimuli that can be identified. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Artist and the Trinity: Dorothy L. Sayers’ Theology of Work by Christine M. FletcherElise M. EdwardsThe Artist and the Trinity: Dorothy L. Sayers’ Theology of Work Christine M. Fletcher eugene, or: pickwick publications, 2013. 162 pp. $19.00.The Artist and the Trinity provides a comprehensive yet concise presentation of Dorothy L. Sayers’s contribution to social ethics and theology, advancing it into a thoughtful, compelling theology of (...) work and vocation. Sayers, a twentieth-century British novelist, playwright, and essayist, highlighted within her writings a consistent set of ideas about work, grounded in deep commitments to the Trinitarian orthodoxy of the Athanasian Creed and the author’s lived experiences as an artist. Christine Fletcher integrates Sayers’s insights into a cohesive theology addressing contemporary problems about work: separation of roles by gendered norms, differentiation of Christian vocation and secular work, and dehumanizing work. [End Page 220]Fletcher skillfully demonstrates that although Sayers was not a professional theologian, apologist, or ethicist, her understanding of the nature of human work and vocation offered a meaningful contribution to Christian social ethics. Early chapters of The Artist and the Trinity feature a well-researched review of Sayers’s works and the ethical themes presented in them. These chapters might capably introduce Sayers to a reader unfamiliar with her work, but the scope and specificity of Fletcher’s discussion of the authors’ characters and plots suggest that this book would best accompany a study of the primary texts. Despite including some literary jargon, Fletcher’s analysis of Sayers’s work is engaging and informative. It exposes the elements of social criticism in Sayers’s fiction and the experiences that informed her analogy for the Trinity. Fletcher offers a thorough description of Sayers’s understanding of the Trinity through an analogy of the artistic process and adeptly explains how it informs Sayers’s conception of good work. Later chapters of the book not only explain “Sayers’ idea that human beings bear the image of God in their ability to create” (xx) but also incorporate this assertion into a compelling human ethic of work that values creativity, initiative, and the individual person’s unique set of skills and interests.The book convincingly argues that good work is an integral part of a fulfilling life for all persons, regardless of gender, because of the universal human capacity to create in the image of God. However, the book lacks any comparison between Sayers’s views on vocation and that of others in the Christian tradition, such as Martin Luther or John Calvin. The omission is striking because Sayers’s belief that the laity’s “secular work is their divine vocation” (120) figures so centrally to her argument about humanity’s desire and ability to make things. But Fletcher effectively contextualizes Sayers’s fiction and wartime speeches, placing her within the tradition of Anglican social ethics, and also skillfully connects her work to contemporary scholarship in theological anthropology, Trinitarian theology, and virtue ethics.The Artist and the Trinity complements other books about Sayers’s theology by Laura Simmons (Creed without Chaos: Exploring Theology in the Writings of Dorothy L. Sayers, Baker Academic, 2005) and Ann Loades (Dorothy L. Sayers: Spiritual Writings, SPCK, 1993). While those works explicate her theological contributions, this study focuses more on the ethical implications of Sayers’s theology. Fletcher’s theology of good work expertly addresses limitations in Sayers’s theology with elements from Alasdair MacIntyre’s philosophical accounts of practices, internal and external goods, and institutions, resulting in an original proposal of work and care. This book is nuanced yet accessible for advanced undergraduates and nonspecialists interested in topics as varied as Trinitarian theology, feminist studies in religion, labor and economics, and Christianity and the arts. While Sayers’s narratives and essays are already valued by religion scholars engaged in the arts and [End Page 221] literature, this study persuasively illuminates the relevance of her work for ethicists pursuing questions about human relationality, gender roles, and the meaning of work.Elise M. EdwardsBaylor UniversityCopyright © 2016 Society of Christian Ethics... (shrink)

Martin Luther King, Jr. was born in the family home on Auburn Ave. in Atlanta, Georgia on January 15, 1929, as the second child of Alberta and Rev. M.L. King. Alberta’s husband had taken up the duties of her father as pastor of the nearby Ebenezer Baptist Church, and her second son was destined to assume leadership of the congregation and community that had nurtured the family life. -/- Along with his older sister, Christine, and his younger brother (...) A.D., the young Martin King enjoyed the kind of security and prestige that would come with life in one of the leading families of Atlanta. He wrote and spoke of a childhood that was experienced with love and fullness. . . . (shrink)

This book should be essential reading for anyone interested in the new reproductive technologies, biomedical ethics, and women's health.

The vast majority of research in nursing ethics over the last decade indicates that nurses may not be fully prepared to ‘deliver the good’ for their patients, or to contribute appropriately in the wider current health care climate. When suitable research projects were evaluated for this article, one key question emerged: if nurses are educationally better prepared than ever before to exercise their ethical decision-making skills, why does research still indicate that the expected practice-based improvements remain elusive? Hence, a number (...) of ideas gleaned from recent research about the current nature of nursing ethics, and especially teaching nursing ethics to student nurses, are analysed and critiqued in this article, which concludes with a cluster of ideas and conclusions based on that analysis. It is hoped that such a review may serve as a catalyst for nurse educators to re-examine their teaching practices with a view to enhancing good nursing practice through educational means. (shrink)

An equivalence between the category of MV-algebras and the category \ is given in Castiglioni et al. :67–92, 2014). An integral residuated lattice with bottom is an MV-algebra if and only if it satisfies the equations \ \vee = 1}\) and \ = a \wedge b}\). An object of \ is a residuated lattice which in particular satisfies some equations which correspond to the previous equations. In this paper we extend the equivalence to the category whose objects are pairs, where (...) A is an MV-algebra and I is an ideal of A. (shrink)

This article re-evaluates the role of the manuscript tradition of the Historia Augusta in debates over the original contents and authorship of the text. Evidence for physical disruptions to the text before our oldest surviving manuscripts points to an earlier manuscript distributed across multiple codices. A multi-volume archetype eliminates critical arguments against the author's claims about lives missing before the Life of Hadrian as well as in the lacuna for the years a.d. 244–260. Other multi-volume codices of the eighth and (...) ninth centuries show that loss of an initial volume would have disrupted the textual tradition for the index, titles and authorial attributions. Comparison of our most complete early witness, Pal. lat. 899, to the independent branches of the textual tradition shows discrepancies between these paratextual elements as expected in a disrupted tradition. Ultimately, this article concludes that the current debates on authorship and the original scope of the Historia Augusta rest on paratextual elements from a single branch of the manuscript tradition, raising doubts about the centrality of these controversies to understanding the work. (shrink)

We extend the construction of a global square sequence in extender models from Zeman [8] to a construction of coherent non-threadable sequences and give a characterization of stationary reflection at inaccessibles similar to Jensen’s characterization in L.

This paper introduces an axiomatisation for equational hybrid logic based on previous axiomatizations and natural deduction systems for propositional and first-order hybrid logic. Its soundness and completeness is discussed. This work is part of a broader research project on the development a general proof calculus for hybrid logics.

In this paper we shall introduce two types of contextual-hierarchical approaches to the strengthened liar problem. These approaches, which we call the ‘standard’ and the ‘alternative’ ch-reconstructions of the strengthened liar problem, differ in their philosophical view regarding the nature of truth and the relation between the truth predicates T r n and T r n+1 of different hierarchy-levels. The basic idea of the standard ch-reconstruction is that the T r n+1-schema should hold for all sentences of \. In contrast, (...) the alternative ch-reconstruction, for which we shall argue in section four, is motivated by the idea that T r n and T r n+1 are coherent in the sense that the same sentences of \ should be true according to T r n and T r n+1. We show that instances of the standard ch-reconstruction can be obtained by iterating Kripke’s strong Kleene jump operator. Furthermore, we will demonstrate how instances of the alternative ch-reconstruction can be obtained by a slight modification of the iterated axiom system KF and of the iterated strong Kleene jump operator. (shrink)

Personal autonomy is often taken to consist in self-government or self-determination. Personal autonomy thus seems to require self-control. However, there is reason to think that autonomy is compatible with the absence of self-control. Akratic action, i.e., action performed against the agent’s better judgement, can be free. And it is also plausible to think that free actions require autonomy. It is only when you determine what you do yourself that you act freely. It follows that akratic actions can be autonomous. At (...) least in some cases, it is the agent herself, and not some alien part of her, who determines her akratic actions. But akratic actions are usually thought to be paradigm cases of self-control failure. Thus, we have reason both to conclude that autonomy requires self-control and that autonomy is compatible with the absence of self-control. My aim is to discuss the main solutions to this paradox. (shrink)